Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-timR/SymE(toxin)
Location 4126310..4126722 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag QET41_RS20110 Protein ID WP_000132614.1
Coordinates 4126381..4126722 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name timR
Locus tag -
Coordinates 4126310..4126386 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS20100 (4122922) 4122922..4124391 + 1470 WP_001387312.1 type I restriction-modification system subunit M -
QET41_RS20105 (4124391) 4124391..4126160 + 1770 WP_001513535.1 restriction endonuclease subunit S -
- (4126310) 4126310..4126386 - 77 NuclAT_8 - Antitoxin
- (4126310) 4126310..4126386 - 77 NuclAT_8 - Antitoxin
- (4126310) 4126310..4126386 - 77 NuclAT_8 - Antitoxin
- (4126310) 4126310..4126386 - 77 NuclAT_8 - Antitoxin
- (4126310) 4126310..4126386 - 77 NuclAT_9 - Antitoxin
- (4126310) 4126310..4126386 - 77 NuclAT_9 - Antitoxin
- (4126310) 4126310..4126386 - 77 NuclAT_9 - Antitoxin
- (4126310) 4126310..4126386 - 77 NuclAT_9 - Antitoxin
QET41_RS20110 (4126381) 4126381..4126722 + 342 WP_000132614.1 endoribonuclease SymE Toxin
QET41_RS20115 (4126769) 4126769..4127932 - 1164 WP_224153787.1 DUF1524 domain-containing protein -
QET41_RS20120 (4127986) 4127986..4128862 - 877 Protein_3938 DUF262 domain-containing protein -
QET41_RS20125 (4129268) 4129268..4130188 - 921 WP_001513532.1 Rpn family recombination-promoting nuclease/putative transposase -
QET41_RS20130 (4130373) 4130373..4131653 + 1281 WP_001338077.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4110698..4126722 16024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T278686 WP_000132614.1 NZ_CP123231:4126381-4126722 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT278686 NZ_CP123231:c4126386-4126310 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References