Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 767066..767759 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QET41_RS03750 Protein ID WP_000415584.1
Coordinates 767066..767362 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QET41_RS03755 Protein ID WP_000650107.1
Coordinates 767364..767759 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS03715 (762154) 762154..762468 - 315 WP_000958598.1 putative quinol monooxygenase -
QET41_RS03720 (762499) 762499..763080 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QET41_RS03725 (763399) 763399..763731 + 333 WP_000917685.1 DUF2645 family protein -
QET41_RS03730 (763777) 763777..765126 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QET41_RS03735 (765123) 765123..765782 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QET41_RS03740 (765934) 765934..766326 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QET41_RS03745 (766379) 766379..766861 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QET41_RS03750 (767066) 767066..767362 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QET41_RS03755 (767364) 767364..767759 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QET41_RS03760 (767892) 767892..769499 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QET41_RS03765 (769637) 769637..771895 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T278672 WP_000415584.1 NZ_CP123231:767066-767362 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT278672 WP_000650107.1 NZ_CP123231:767364-767759 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References