Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 2819224..2819897 Replicon chromosome
Accession NZ_CP123003
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QC756_RS13885 Protein ID WP_010969926.1
Coordinates 2819493..2819897 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID H0GA10
Locus tag QC756_RS13880 Protein ID WP_003536345.1
Coordinates 2819224..2819496 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS13860 (QC756_13860) 2815215..2816855 - 1641 WP_003536336.1 ABC transporter substrate-binding protein -
QC756_RS13865 (QC756_13865) 2816903..2817958 - 1056 WP_010969924.1 dipeptidase -
QC756_RS13870 (QC756_13870) 2818138..2818479 - 342 WP_003536339.1 SMR family transporter -
QC756_RS13875 (QC756_13875) 2818527..2819087 - 561 WP_010969925.1 TetR/AcrR family transcriptional regulator -
QC756_RS13880 (QC756_13880) 2819224..2819496 + 273 WP_003536345.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QC756_RS13885 (QC756_13885) 2819493..2819897 + 405 WP_010969926.1 type II toxin-antitoxin system VapC family toxin Toxin
QC756_RS13890 (QC756_13890) 2820025..2820417 + 393 WP_003536349.1 globin -
QC756_RS13895 (QC756_13895) 2820423..2820797 + 375 WP_010969927.1 DUF423 domain-containing protein -
QC756_RS13900 (QC756_13900) 2820920..2821180 + 261 WP_010969928.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QC756_RS13905 (QC756_13905) 2821295..2821609 - 315 WP_003536354.1 antibiotic biosynthesis monooxygenase -
QC756_RS13910 (QC756_13910) 2821622..2821888 - 267 WP_010969929.1 hypothetical protein -
QC756_RS13915 (QC756_13915) 2821941..2822354 - 414 WP_003536357.1 DUF2325 domain-containing protein -
QC756_RS13920 (QC756_13920) 2822562..2823488 - 927 WP_010969930.1 energy transducer TonB -
QC756_RS13925 (QC756_13925) 2823529..2823963 - 435 WP_010969931.1 hypothetical protein -
QC756_RS13930 (QC756_13930) 2824193..2824333 + 141 WP_010969932.1 hemin uptake protein HemP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14747.98 Da        Isoelectric Point: 5.1974

>T278336 WP_010969926.1 NZ_CP123003:2819493-2819897 [Sinorhizobium meliloti]
MNGYLLDTNIISDVIHNPFGPAAQRIERIGPKEIYTSIVVASELRYGCAKKGSAKLLAKVESLLEIVPVLPLDIPADTRY
GSIRAELESLGQTIGSNDLLIAAHAYALDLTLVTDNIREFSRVRGLSLENWLER

Download         Length: 405 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10334.02 Da        Isoelectric Point: 6.3950

>AT278336 WP_003536345.1 NZ_CP123003:2819224-2819496 [Sinorhizobium meliloti]
MPVPLPSSRPKEVKLFRNNRSQAVRIPAEFELPGDRVLIRREGTRLIIEPIARPADIVELLAEWKKEAPLGPEDRFPDVE
DIPARPEKIF

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0GA10

References