Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 497793..498447 Replicon chromosome
Accession NZ_CP122947
Organism Helicobacter pylori strain BS07

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag QAD57_RS02255 Protein ID WP_000271050.1
Coordinates 497793..498077 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QAD57_RS02260 Protein ID WP_286446123.1
Coordinates 498058..498447 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAD57_RS02235 (QAD57_02235) 494376..495143 - 768 WP_286446117.1 ABC transporter ATP-binding protein -
QAD57_RS02240 (QAD57_02240) 495143..496123 - 981 WP_000921458.1 iron chelate uptake ABC transporter family permease subunit -
QAD57_RS02245 (QAD57_02245) 496116..496958 - 843 WP_286446120.1 SDR family oxidoreductase -
QAD57_RS02250 (QAD57_02250) 497098..497619 + 522 WP_286446122.1 acyl-CoA thioesterase -
QAD57_RS02255 (QAD57_02255) 497793..498077 - 285 WP_000271050.1 endoribonuclease VapD Toxin
QAD57_RS02260 (QAD57_02260) 498058..498447 - 390 WP_286446123.1 hypothetical protein Antitoxin
QAD57_RS02265 (QAD57_02265) 498968..501193 - 2226 WP_286446124.1 Hop family adhesin BabA -
QAD57_RS02280 (QAD57_02280) 501705..502226 + 522 WP_286446126.1 hypothetical protein -
QAD57_RS02285 (QAD57_02285) 502177..503289 - 1113 WP_286446128.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T278287 WP_000271050.1 NZ_CP122947:c498077-497793 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 15056.11 Da        Isoelectric Point: 8.2592

>AT278287 WP_286446123.1 NZ_CP122947:c498447-498058 [Helicobacter pylori]
MPNSPAKKDYTQYSEKQLFNLINQLEQKIKRMQNRASFKEKMANELEKRDQNFKDKIDALNELLQKISQAFDDKRGCCLW
HKIPSIQTQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure

References