Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2046796..2047298 Replicon chromosome
Accession NZ_CP122880
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QDX09_RS10035 Protein ID WP_000767829.1
Coordinates 2047044..2047298 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S1Y4D6
Locus tag QDX09_RS10030 Protein ID WP_001259254.1
Coordinates 2046796..2047047 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS10005 (2041974) 2041974..2043041 - 1068 WP_000080035.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDX09_RS10010 (2043041) 2043041..2044111 - 1071 WP_000108986.1 histidinol-phosphate transaminase -
QDX09_RS10015 (2044108) 2044108..2045412 - 1305 WP_046788605.1 histidinol dehydrogenase -
QDX09_RS10020 (2045418) 2045418..2046317 - 900 WP_000131770.1 ATP phosphoribosyltransferase -
QDX09_RS10025 (2046463) 2046463..2046513 - 51 WP_001364200.1 his operon leader peptide -
QDX09_RS10030 (2046796) 2046796..2047047 + 252 WP_001259254.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDX09_RS10035 (2047044) 2047044..2047298 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDX09_RS10040 (2047381) 2047381..2048205 + 825 WP_000754737.1 SDR family oxidoreductase -
QDX09_RS10045 (2048251) 2048251..2049180 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDX09_RS10050 (2049394) 2049394..2049456 + 63 WP_010723108.1 membrane protein YoeI -
QDX09_RS10055 (2049446) 2049446..2050804 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDX09_RS10060 (2050982) 2050982..2052040 + 1059 WP_000492313.1 thiosulfate utilization transporter TsuA/YeeE -
QDX09_RS10065 (2052054) 2052054..2052281 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T278181 WP_000767829.1 NZ_CP122880:2047044-2047298 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9292.57 Da        Isoelectric Point: 4.5822

>AT278181 WP_001259254.1 NZ_CP122880:2046796-2047047 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGIGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A2S1Y4D6

References