Detailed information of TA system TA278152

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 65376..65792
• Replicon: plasmid unnamed2
• Accession: NZ_CP122874
• Organism: Escherichia coli strain ETEC1718

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QDX06_RS26230
• Protein ID: WP_247141765.1
• Coordinates: 65670..65792 (+)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	65376..65585 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDX06_RS26195	61060..61593	+	534	WP_032085149.1	single-stranded DNA-binding protein	-
QDX06_RS26200	61651..61884	+	234	WP_032085150.1	DUF905 family protein	-
QDX06_RS26205	61950..63908	+	1959	WP_089637074.1	ParB/RepB/Spo0J family partition protein	-
QDX06_RS26210	63963..64397	+	435	Protein_70	conjugation system SOS inhibitor PsiB	-
QDX06_RS26215	64394..65113	+	720	WP_032085152.1	plasmid SOS inhibition protein A	-
QDX06_RS26220	65110..65424	+	315	WP_089637073.1	theronine dehydrogenase	-
-	65373..65585	+	213	NuclAT_0	-	-
-	65373..65585	+	213	NuclAT_0	-	-
-	65373..65585	+	213	NuclAT_0	-	-
-	65373..65585	+	213	NuclAT_0	-	-
-	65376..65585	-	210	-	-	Antitoxin
QDX06_RS26225	65573..65725	+	153	Protein_73	DUF5431 family protein	-
QDX06_RS26230	65670..65792	+	123	WP_247141765.1	Hok/Gef family protein	Toxin
QDX06_RS26235	66149..66799	+	651	WP_000993931.1	IS66-like element accessory protein TnpA	-
QDX06_RS26240	66799..67146	+	348	WP_213833996.1	IS66 family insertion sequence element accessory protein TnpB	-
QDX06_RS26245	67242..68309	+	1068	Protein_77	IS66-like element ISCro1 family transposase	-
QDX06_RS26250	68431..68643	-	213	WP_032084501.1	hypothetical protein	-
QDX06_RS26255	68776..69336	-	561	WP_001523482.1	fertility inhibition protein FinO	-
QDX06_RS26260	69391..70137	-	747	WP_001523483.1	conjugal transfer pilus acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102370	102370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-35)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4562.36 Da
• Isoelectric Point: 8.2774

>T278152 WP_247141765.1 NZ_CP122874:65670-65792 [Escherichia coli]
IVCCTLLIFTHLTRNRLCEVRLKDGYREVTATMAYESGGK

Nucleotide

• Length: 123 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT278152 NZ_CP122874:c65585-65376 [Escherichia coli]
GTGGACTAGACATGCAGAGGCCTCGTGGGTTAATGAAAATTAACTACGGGGCTTTTGTCCTTCTGCCACACGACAGGATA
ACAAACCACCTTCACGTCATGAGGCAGAAAGCCTCAAGCGCCGGGCACATCATAGCCCATATACCTGCACGCTGACCACA
TTCACTTTCCCTGAAAATAATCCGGTCGTTCAGCCAGTTCACGGGCAATC

Structures

Antitoxin