Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 293109..293695 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag QDX04_RS01355 Protein ID WP_042014162.1
Coordinates 293109..293339 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QDX04_RS01360 Protein ID WP_000593555.1
Coordinates 293336..293695 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS01345 (289146) 289146..291881 + 2736 WP_028132003.1 ribosome-associated ATPase/putative transporter RbbA -
QDX04_RS01350 (291881) 291881..293005 + 1125 WP_001216257.1 ABC transporter permease -
QDX04_RS01355 (293109) 293109..293339 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
QDX04_RS01360 (293336) 293336..293695 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDX04_RS01365 (293815) 293815..294216 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QDX04_RS01370 (294222) 294222..295028 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QDX04_RS01375 (295025) 295025..295789 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QDX04_RS01380 (295789) 295789..296622 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QDX04_RS01385 (296619) 296619..297563 - 945 WP_152072116.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T278108 WP_042014162.1 NZ_CP122868:293109-293339 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT278108 WP_000593555.1 NZ_CP122868:293336-293695 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References