278056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1803040..1803542 Replicon chromosome
Accession NZ_CP122844
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag QDX00_RS08750 Protein ID WP_000767820.1
Coordinates 1803288..1803542 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QDX00_RS08745 Protein ID WP_001259255.1
Coordinates 1803040..1803291 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS08720 (1798217) 1798217..1799284 - 1068 WP_072668050.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDX00_RS08725 (1799284) 1799284..1800354 - 1071 WP_000108928.1 histidinol-phosphate transaminase -
QDX00_RS08730 (1800351) 1800351..1801655 - 1305 WP_000009586.1 histidinol dehydrogenase -
QDX00_RS08735 (1801661) 1801661..1802560 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QDX00_RS08740 (1802706) 1802706..1802756 - 51 WP_001364200.1 his operon leader peptide -
QDX00_RS08745 (1803040) 1803040..1803291 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDX00_RS08750 (1803288) 1803288..1803542 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDX00_RS08755 (1803625) 1803625..1804449 + 825 WP_000754756.1 SDR family oxidoreductase -
QDX00_RS08760 (1804495) 1804495..1805424 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDX00_RS08765 (1805639) 1805639..1805701 + 63 WP_010723108.1 membrane protein YoeI -
QDX00_RS08770 (1805691) 1805691..1807049 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDX00_RS08775 (1807228) 1807228..1808286 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
QDX00_RS08780 (1808300) 1808300..1808527 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T278056 WP_000767820.1 NZ_CP122844:1803288-1803542 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT278056 WP_001259255.1 NZ_CP122844:1803040-1803291 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References