Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 584050..584849 Replicon chromosome
Accession NZ_CP122844
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDX00_RS02885 Protein ID WP_000347273.1
Coordinates 584050..584514 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX00_RS02890 Protein ID WP_001307405.1
Coordinates 584514..584849 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS02855 (579051) 579051..579485 - 435 WP_000948842.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX00_RS02860 (579503) 579503..580381 - 879 WP_094314169.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX00_RS02865 (580371) 580371..581150 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX00_RS02870 (581161) 581161..581634 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX00_RS02875 (581657) 581657..582937 - 1281 WP_196011018.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX00_RS02880 (583186) 583186..583995 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDX00_RS02885 (584050) 584050..584514 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX00_RS02890 (584514) 584514..584849 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX00_RS02895 (584998) 584998..586569 - 1572 WP_001273753.1 galactarate dehydratase -
QDX00_RS02900 (586944) 586944..588278 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDX00_RS02905 (588294) 588294..589064 + 771 WP_196011017.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T278050 WP_000347273.1 NZ_CP122844:c584514-584050 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278050 WP_001307405.1 NZ_CP122844:c584849-584514 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References