Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2199742..2200213 Replicon chromosome
Accession NC_017906
Organism Escherichia coli Xuzhou21

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag CDCO157_RS11460 Protein ID WP_001303511.1
Coordinates 2199935..2200213 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag CDCO157_RS11455 Protein ID WP_001302048.1
Coordinates 2199742..2199933 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCO157_RS11410 2194949..2195533 - 585 WP_000206793.1 DUF551 domain-containing protein -
CDCO157_RS11415 2195590..2195985 - 396 WP_001118159.1 DUF977 family protein -
CDCO157_RS11420 2196001..2196770 - 770 Protein_2156 DUF1627 domain-containing protein -
CDCO157_RS11430 2196796..2197536 - 741 WP_000788938.1 ATP-binding protein -
CDCO157_RS11435 2197543..2198505 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
CDCO157_RS11440 2198528..2198953 - 426 WP_000693943.1 Rha family transcriptional regulator -
CDCO157_RS11445 2198950..2199252 - 303 WP_000172738.1 transcriptional regulator -
CDCO157_RS31265 2199350..2199721 + 372 WP_001169686.1 hypothetical protein -
CDCO157_RS11455 2199742..2199933 + 192 WP_001302048.1 hypothetical protein Antitoxin
CDCO157_RS11460 2199935..2200213 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDCO157_RS11470 2200566..2200865 + 300 WP_001240334.1 hypothetical protein -
CDCO157_RS11475 2200937..2201155 + 219 WP_001171930.1 hypothetical protein -
CDCO157_RS29545 2201724..2201912 + 189 WP_000449192.1 cell division inhibition protein DicB -
CDCO157_RS11480 2201909..2202100 + 192 WP_001090200.1 DUF1482 family protein -
CDCO157_RS11485 2202193..2204664 + 2472 WP_000048458.1 exonuclease -
CDCO157_RS11490 2204737..2204988 + 252 WP_000005552.1 excisionase family protein -
CDCO157_RS32240 2205023..2205207 + 185 Protein_2170 DUF3596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2107725..2207374 99649


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T27778 WP_001303511.1 NC_017906:2199935-2200213 [Escherichia coli Xuzhou21]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T27778 NC_017906:2199935-2200213 [Escherichia coli Xuzhou21]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT27778 WP_001302048.1 NC_017906:2199742-2199933 [Escherichia coli Xuzhou21]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT27778 NC_017906:2199742-2199933 [Escherichia coli Xuzhou21]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References