Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 743522..744357 Replicon chromosome
Accession NZ_CP122712
Organism Escherichia coli strain ETEC1749

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8S7S8K0
Locus tag QDX02_RS03635 Protein ID WP_000854723.1
Coordinates 743980..744357 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7S6L8
Locus tag QDX02_RS03630 Protein ID WP_001285573.1
Coordinates 743522..743890 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX02_RS03610 (741238) 741238..742056 + 819 WP_032167344.1 DUF932 domain-containing protein -
QDX02_RS03615 (742148) 742148..742642 + 495 WP_032167345.1 antirestriction protein -
QDX02_RS03620 (742658) 742658..743134 + 477 WP_001360063.1 RadC family protein -
QDX02_RS03625 (743221) 743221..743442 + 222 WP_000692176.1 DUF987 domain-containing protein -
QDX02_RS03630 (743522) 743522..743890 + 369 WP_001285573.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDX02_RS03635 (743980) 743980..744357 + 378 WP_000854723.1 TA system toxin CbtA family protein Toxin
QDX02_RS03640 (744354) 744354..744842 + 489 WP_000761669.1 DUF5983 family protein -
QDX02_RS03645 (744854) 744854..745051 + 198 WP_000772035.1 DUF957 domain-containing protein -
QDX02_RS03650 (745148) 745148..745993 + 846 WP_001290254.1 DUF4942 domain-containing protein -
QDX02_RS03660 (746727) 746727..748979 + 2253 Protein_718 alpha-amylase family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14145.23 Da        Isoelectric Point: 8.2904

>T277718 WP_000854723.1 NZ_CP122712:743980-744357 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRTRRATGLMARDNYRTVNNIILGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13585.33 Da        Isoelectric Point: 6.3159

>AT277718 WP_001285573.1 NZ_CP122712:743522-743890 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCSVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References