Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49193..50025 Replicon chromosome
Accession NZ_CP122655
Organism Escherichia coli strain ETEC4074

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag QDW60_RS00255 Protein ID WP_000854753.1
Coordinates 49193..49567 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag QDW60_RS00260 Protein ID WP_001280951.1
Coordinates 49657..50025 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW60_RS00225 (44559) 44559..45482 - 924 WP_000535963.1 carboxylate/amino acid/amine transporter -
QDW60_RS00230 (45593) 45593..46777 - 1185 WP_001172876.1 sugar efflux transporter -
QDW60_RS00235 (47174) 47174..47335 - 162 Protein_46 RhuM family protein -
QDW60_RS00240 (47569) 47569..48414 - 846 WP_001406222.1 DUF4942 domain-containing protein -
QDW60_RS00245 (48499) 48499..48696 - 198 WP_000839243.1 DUF957 domain-containing protein -
QDW60_RS00250 (48708) 48708..49196 - 489 WP_001549830.1 DUF5983 family protein -
QDW60_RS00255 (49193) 49193..49567 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
QDW60_RS00260 (49657) 49657..50025 - 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDW60_RS00265 (50188) 50188..50409 - 222 WP_001405861.1 DUF987 domain-containing protein -
QDW60_RS00270 (50478) 50478..50954 - 477 WP_033566565.1 RadC family protein -
QDW60_RS00275 (50970) 50970..51455 - 486 WP_001469549.1 antirestriction protein -
QDW60_RS00280 (51510) 51510..52328 - 819 WP_001234620.1 DUF932 domain-containing protein -
QDW60_RS00285 (52428) 52428..52661 - 234 WP_001119729.1 DUF905 family protein -
QDW60_RS00290 (52740) 52740..53196 - 457 Protein_57 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T277550 WP_000854753.1 NZ_CP122655:c49567-49193 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT277550 WP_001280951.1 NZ_CP122655:c50025-49657 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References