Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 98118..98382 Replicon plasmid unnamed7
Accession NZ_CP122641
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name pndA Uniprot ID E6BRV3
Locus tag QDW62_RS29425 Protein ID WP_001303307.1
Coordinates 98118..98270 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 98320..98382 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS29400 (93127) 93127..95295 + 2169 WP_282840388.1 DotA/TraY family protein -
QDW62_RS29405 (95360) 95360..96022 + 663 WP_077738432.1 plasmid IncI1-type surface exclusion protein ExcA -
QDW62_RS29410 (96094) 96094..96303 - 210 WP_000062603.1 HEAT repeat domain-containing protein -
QDW62_RS29415 (96695) 96695..96871 + 177 WP_001054900.1 hypothetical protein -
- (97357) 97357..97408 + 52 NuclAT_1 - -
- (97357) 97357..97408 + 52 NuclAT_1 - -
- (97357) 97357..97408 + 52 NuclAT_1 - -
- (97357) 97357..97408 + 52 NuclAT_1 - -
QDW62_RS29420 (97795) 97795..98046 + 252 WP_001291965.1 hypothetical protein -
QDW62_RS29425 (98118) 98118..98270 - 153 WP_001303307.1 Hok/Gef family protein Toxin
- (98320) 98320..98382 + 63 NuclAT_0 - Antitoxin
- (98320) 98320..98382 + 63 NuclAT_0 - Antitoxin
- (98320) 98320..98382 + 63 NuclAT_0 - Antitoxin
- (98320) 98320..98382 + 63 NuclAT_0 - Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..98561 98561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.21 Da        Isoelectric Point: 8.7948

>T277469 WP_001303307.1 NZ_CP122641:c98270-98118 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

Antitoxin


Download         Length: 63 bp

>AT277469 NZ_CP122641:98320-98382 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A634Q5L1

Antitoxin

Download structure file

References