Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 47628..48187 Replicon plasmid unnamed7
Accession NZ_CP122641
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag QDW62_RS29175 Protein ID WP_000421259.1
Coordinates 47628..47903 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U0BV64
Locus tag QDW62_RS29180 Protein ID WP_001178090.1
Coordinates 47903..48187 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS29140 (42632) 42632..43126 + 495 WP_015058884.1 hypothetical protein -
QDW62_RS29145 (43126) 43126..43392 + 267 WP_000627832.1 hypothetical protein -
QDW62_RS29150 (43631) 43631..43996 + 366 WP_000124098.1 hypothetical protein -
QDW62_RS29155 (43996) 43996..45183 + 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDW62_RS29160 (45460) 45460..45825 + 366 WP_000091308.1 hypothetical protein -
QDW62_RS29165 (45825) 45825..47012 + 1188 WP_000937591.1 IS91 family transposase -
QDW62_RS29170 (47319) 47319..47522 - 204 Protein_60 hypothetical protein -
QDW62_RS29175 (47628) 47628..47903 - 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW62_RS29180 (47903) 47903..48187 - 285 WP_001178090.1 ribbon-helix-helix domain-containing protein Antitoxin
QDW62_RS29185 (49093) 49093..50124 - 1032 WP_022630251.1 plasmid replication initiator RepA -
QDW62_RS29190 (51081) 51081..51239 + 159 Protein_64 ash family protein -
QDW62_RS29195 (51277) 51277..51564 + 288 WP_000074849.1 conjugal transfer protein TraA -
QDW62_RS29200 (52006) 52006..52539 + 534 WP_001372168.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..98561 98561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T277468 WP_000421259.1 NZ_CP122641:c47903-47628 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10487.94 Da        Isoelectric Point: 6.4613

>AT277468 WP_001178090.1 NZ_CP122641:c48187-47903 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMANKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB A0A7U0BV64

References