Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3959463..3960004 Replicon chromosome
Accession NZ_CP122629
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag QDW58_RS19390 Protein ID WP_000615982.1
Coordinates 3959726..3960004 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QDW58_RS19385 Protein ID WP_000729704.1
Coordinates 3959463..3959723 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS19360 (3954499) 3954499..3955638 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
QDW58_RS19365 (3955622) 3955622..3957715 + 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
QDW58_RS19370 (3957820) 3957820..3958098 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QDW58_RS19375 (3958091) 3958091..3958447 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
QDW58_RS19380 (3958504) 3958504..3959277 - 774 WP_000543899.1 C40 family peptidase -
QDW58_RS19385 (3959463) 3959463..3959723 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDW58_RS19390 (3959726) 3959726..3960004 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDW58_RS19395 (3960160) 3960160..3960900 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDW58_RS19400 (3960871) 3960871..3961638 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDW58_RS19405 (3961844) 3961844..3962422 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T277422 WP_000615982.1 NZ_CP122629:3959726-3960004 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT277422 WP_000729704.1 NZ_CP122629:3959463-3959723 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References