Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3314671..3315376 Replicon chromosome
Accession NZ_CP122600
Organism Escherichia coli strain ETEC6333

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDX83_RS16425 Protein ID WP_063085620.1
Coordinates 3314671..3315057 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDX83_RS16430 Protein ID WP_219804798.1
Coordinates 3315047..3315376 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX83_RS16405 (3310676) 3310676..3311302 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDX83_RS16410 (3311299) 3311299..3312413 - 1115 Protein_3218 aldose sugar dehydrogenase YliI -
QDX83_RS16415 (3312524) 3312524..3312907 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDX83_RS16420 (3313120) 3313120..3314445 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDX83_RS16425 (3314671) 3314671..3315057 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX83_RS16430 (3315047) 3315047..3315376 + 330 WP_219804798.1 DNA-binding transcriptional regulator Antitoxin
QDX83_RS16435 (3315446) 3315446..3316774 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDX83_RS16440 (3316782) 3316782..3319130 - 2349 WP_021523051.1 EAL domain-containing protein -
QDX83_RS16445 (3319308) 3319308..3320219 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277286 WP_063085620.1 NZ_CP122600:3314671-3315057 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11964.04 Da        Isoelectric Point: 10.0101

>AT277286 WP_219804798.1 NZ_CP122600:3315047-3315376 [Escherichia coli]
MSDKLQMMLEDAKELNALGLISDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References