Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 81715..82358 Replicon plasmid unnamed3
Accession NZ_CP122495
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag QC807_RS26055 Protein ID WP_001044768.1
Coordinates 81942..82358 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag QC807_RS26050 Protein ID WP_001261287.1
Coordinates 81715..81945 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS26035 (77826) 77826..78914 + 1089 WP_000952231.1 hypothetical protein -
QC807_RS26040 (78916) 78916..79785 + 870 WP_000253407.1 hypothetical protein -
QC807_RS26045 (79842) 79842..81407 - 1566 WP_000741348.1 AAA family ATPase -
QC807_RS26050 (81715) 81715..81945 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QC807_RS26055 (81942) 81942..82358 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
QC807_RS26060 (82520) 82520..84658 - 2139 WP_000350635.1 AAA family ATPase -
QC807_RS26065 (85012) 85012..85269 + 258 WP_000343085.1 hypothetical protein -
QC807_RS26070 (85269) 85269..85858 + 590 Protein_107 hypothetical protein -
QC807_RS26075 (86144) 86144..86848 + 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / oqxA / oqxB / aph(3')-IIa / blaTEM-1B / blaCTX-M-55 - 1..95954 95954


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T277025 WP_001044768.1 NZ_CP122495:81942-82358 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT277025 WP_001261287.1 NZ_CP122495:81715-81945 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References