Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 20439..21082 Replicon plasmid unnamed1
Accession NZ_CP122493
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag QC807_RS23905 Protein ID WP_001034046.1
Coordinates 20439..20855 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag QC807_RS23910 Protein ID WP_097309516.1
Coordinates 20852..21082 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS23890 (15644) 15644..16060 - 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
QC807_RS23895 (16057) 16057..16287 - 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
QC807_RS23900 (16600) 16600..20394 + 3795 WP_253180042.1 pcar -
QC807_RS23905 (20439) 20439..20855 - 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
QC807_RS23910 (20852) 20852..21082 - 231 WP_097309516.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QC807_RS23915 (21318) 21318..21809 + 492 WP_000528930.1 HEPN family nuclease -
QC807_RS23920 (21821) 21821..22579 + 759 WP_253180041.1 hypothetical protein -
QC807_RS23925 (22870) 22870..24393 + 1524 WP_000921251.1 hypothetical protein -
QC807_RS23930 (24428) 24428..25552 + 1125 WP_253180040.1 hypothetical protein -
QC807_RS23935 (25552) 25552..25842 + 291 WP_000648897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / tet(A) / blaTEM-1B iucA / iucB / iucC / iucD / iutA / afaC-I 1..207405 207405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T277016 WP_001034046.1 NZ_CP122493:c20855-20439 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8811.02 Da        Isoelectric Point: 4.6282

>AT277016 WP_097309516.1 NZ_CP122493:c21082-20852 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRELDFEGVSELEIIREGNSIILRPVRPTWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure

References