Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 6184..6731 Replicon plasmid unnamed1
Accession NZ_CP122493
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QC807_RS23840 Protein ID WP_244566858.1
Coordinates 6184..6462 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QC807_RS23845 Protein ID WP_000079941.1
Coordinates 6462..6731 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS23815 (3167) 3167..3427 + 261 WP_000371881.1 hypothetical protein -
QC807_RS23820 (3424) 3424..4014 + 591 WP_001376212.1 hypothetical protein -
QC807_RS23825 (4032) 4032..4379 - 348 WP_000142441.1 DUF6404 family protein -
QC807_RS23830 (4691) 4691..5173 - 483 WP_001311056.1 hypothetical protein -
QC807_RS23835 (5290) 5290..6138 - 849 WP_063501806.1 3'-5' exonuclease -
QC807_RS23840 (6184) 6184..6462 - 279 WP_244566858.1 type II toxin-antitoxin system toxin YacB Toxin
QC807_RS23845 (6462) 6462..6731 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QC807_RS23850 (7342) 7342..8616 + 1275 WP_000489607.1 HlyD family secretion protein -
QC807_RS23855 (8609) 8609..10705 + 2097 WP_001402528.1 peptidase domain-containing ABC transporter -
QC807_RS23860 (10875) 10875..11186 - 312 WP_001259758.1 colicin V -
QC807_RS23865 (11164) 11164..11400 - 237 WP_014640552.1 colicin V immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / tet(A) / blaTEM-1B iucA / iucB / iucC / iucD / iutA / afaC-I 1..207405 207405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10757.34 Da        Isoelectric Point: 8.4615

>T277014 WP_244566858.1 NZ_CP122493:c6462-6184 [Escherichia coli]
MEVFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT277014 WP_000079941.1 NZ_CP122493:c6731-6462 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References