Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4710446..4711048 Replicon chromosome
Accession NZ_CP122492
Organism Escherichia coli strain a15

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QC807_RS22820 Protein ID WP_000897305.1
Coordinates 4710737..4711048 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QC807_RS22815 Protein ID WP_000356397.1
Coordinates 4710446..4710736 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC807_RS22790 (4706371) 4706371..4707273 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QC807_RS22795 (4707270) 4707270..4707905 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QC807_RS22800 (4707902) 4707902..4708831 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QC807_RS22805 (4709161) 4709161..4709403 - 243 WP_001087409.1 protein YiiF -
QC807_RS22810 (4709623) 4709623..4709841 - 219 WP_001315930.1 CopG family transcriptional regulator -
QC807_RS22815 (4710446) 4710446..4710736 - 291 WP_000356397.1 NadS family protein Antitoxin
QC807_RS22820 (4710737) 4710737..4711048 - 312 WP_000897305.1 hypothetical protein Toxin
QC807_RS22825 (4711277) 4711277..4712185 + 909 WP_001162704.1 alpha/beta hydrolase -
QC807_RS22830 (4712249) 4712249..4713190 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QC807_RS22835 (4713235) 4713235..4713672 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QC807_RS22840 (4713669) 4713669..4714541 - 873 WP_000920762.1 virulence factor BrkB family protein -
QC807_RS22845 (4714535) 4714535..4715134 - 600 WP_001295269.1 glucose-1-phosphatase -
QC807_RS22850 (4715233) 4715233..4716018 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T277013 WP_000897305.1 NZ_CP122492:c4711048-4710737 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT277013 WP_000356397.1 NZ_CP122492:c4710736-4710446 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References