Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3802774..3803315 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QCG49_RS18450 Protein ID WP_000615983.1
Coordinates 3803037..3803315 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QCG49_RS18445 Protein ID WP_000729703.1
Coordinates 3802774..3803034 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS18425 (3798449) 3798449..3799234 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QCG49_RS18430 (3799206) 3799206..3800918 + 1713 Protein_3590 flagellar biosynthesis protein FlhA -
QCG49_RS18435 (3801142) 3801142..3801639 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QCG49_RS18440 (3801815) 3801815..3802564 - 750 WP_000056849.1 C40 family peptidase -
QCG49_RS18445 (3802774) 3802774..3803034 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QCG49_RS18450 (3803037) 3803037..3803315 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QCG49_RS18455 (3803471) 3803471..3804211 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QCG49_RS18460 (3804182) 3804182..3804949 - 768 WP_000333380.1 class II glutamine amidotransferase -
QCG49_RS18465 (3805155) 3805155..3805733 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T276710 WP_000615983.1 NZ_CP122317:3803037-3803315 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT276710 WP_000729703.1 NZ_CP122317:3802774-3803034 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References