Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4054088..4055681 Replicon chromosome
Accession NZ_CP121795
Organism Aeromonas dhakensis strain DAMIAN 12594

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QBS05_RS18780 Protein ID WP_017765666.1
Coordinates 4054365..4055681 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QBS05_RS18775 Protein ID WP_041202615.1
Coordinates 4054088..4054381 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBS05_RS18755 4050873..4052267 + 1395 WP_279461854.1 NACHT domain-containing protein -
QBS05_RS18760 4052495..4052710 + 216 WP_279461855.1 hypothetical protein -
QBS05_RS18765 4052952..4053278 + 327 WP_279461856.1 hypothetical protein -
QBS05_RS18770 4053265..4053807 - 543 WP_279461857.1 metal-dependent hydrolase -
QBS05_RS18775 4054088..4054381 + 294 WP_041202615.1 helix-turn-helix domain-containing protein Antitoxin
QBS05_RS18780 4054365..4055681 + 1317 WP_017765666.1 HipA domain-containing protein Toxin
QBS05_RS18785 4055780..4056022 + 243 WP_005302916.1 DUF3297 family protein -
QBS05_RS18790 4056220..4056762 + 543 WP_279461858.1 beta/gamma crystallin-related protein -
QBS05_RS18795 4056832..4057275 - 444 WP_187590450.1 inhibitor of vertebrate lysozyme family protein -
QBS05_RS18800 4057457..4058668 - 1212 WP_010633406.1 NupC/NupG family nucleoside CNT transporter -
QBS05_RS18805 4059151..4060305 + 1155 WP_017780799.1 YdcF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-73)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49597.67 Da        Isoelectric Point: 6.0490

>T276575 WP_017765666.1 NZ_CP121795:4054365-4055681 [Aeromonas dhakensis]
MMNGSEHHRLELRLGNQLIGHLEYDSNRDSFQLGYLPEWQARGFPLSPPLALDGSASSAQIRAYLGNLLPENRGLDHLIE
VLSVSRSNLFALIHGIGRDVSGAVTFTLPAEPDIPTRFRPITPEELMLRLDQPEIWPLEVWDGRPRLSVAGVQAKLNLLR
LEGRLGFGEGELCSTHLLKFEHHPHLVINEFVTMQLAAQLSMPVARVELHTVGQGEKSHRSLLVERFDRRLDEDGMRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLFSLSALCVNPAQARLDMLQWLLFNLCVNNHDAHGKNYSFF
VSKAGLTPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAINAWQLLEMAEACDLPERLLQQTLQKIASDILHHLDAAIAM
VETDHPAELDYLARYKDDVERRCHHFQEQAGLLPELQL

Download         Length: 1317 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10570.25 Da        Isoelectric Point: 6.2983

>AT276575 WP_041202615.1 NZ_CP121795:4054088-4054381 [Aeromonas dhakensis]
MTDTPLPTGTKELDPASLGLAIRERRKAAKMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQEAGS
QVMSSYSQPEVGDDEWF

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References