Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1177206..1177818 Replicon chromosome
Accession NZ_CP121354
Organism Mesorhizobium sp. WSM4904

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QAZ47_RS05600 Protein ID WP_278232798.1
Coordinates 1177206..1177502 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QAZ47_RS05605 Protein ID WP_278206016.1
Coordinates 1177510..1177818 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAZ47_RS05575 (QAZ47_05575) 1173417..1174190 + 774 WP_278232794.1 FadR/GntR family transcriptional regulator -
QAZ47_RS05580 (QAZ47_05580) 1174207..1175058 + 852 WP_278207791.1 5-dehydro-4-deoxy-D-glucuronate isomerase -
QAZ47_RS05585 (QAZ47_05585) 1175055..1175822 + 768 WP_278232795.1 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD -
QAZ47_RS05590 (QAZ47_05590) 1175851..1176183 + 333 WP_278232796.1 cupin domain-containing protein -
QAZ47_RS05595 (QAZ47_05595) 1176455..1177081 - 627 WP_278232797.1 LysE family translocator -
QAZ47_RS05600 (QAZ47_05600) 1177206..1177502 + 297 WP_278232798.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QAZ47_RS05605 (QAZ47_05605) 1177510..1177818 + 309 WP_278206016.1 HigA family addiction module antitoxin Antitoxin
QAZ47_RS05610 (QAZ47_05610) 1177954..1179807 + 1854 WP_278232799.1 DNA helicase RecQ -
QAZ47_RS05615 (QAZ47_05615) 1179845..1180822 - 978 WP_278232800.1 DUF1186 domain-containing protein -
QAZ47_RS05620 (QAZ47_05620) 1181071..1182204 + 1134 WP_278232801.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11864.43 Da        Isoelectric Point: 6.8813

>T276276 WP_278232798.1 NZ_CP121354:1177206-1177502 [Mesorhizobium sp. WSM4904]
MILGFRDEWLRAFFVDDAHSRNIPFDLELRLFRKLQMIDDAMTDPDLRVPPSNHFEKLRGNLEGFHSIRVNKQWRLVFRW
DGRRGEASDVYLDDHSYR

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11702.64 Da        Isoelectric Point: 11.3562

>AT276276 WP_278206016.1 NZ_CP121354:1177510-1177818 [Mesorhizobium sp. WSM4904]
MLATKRRPVTIGEILVEEFMRPMGLTQAALAEAMGVQRKHVNELCNNRRNVTAPTALILARVFGNSPEFWLNVQRRSDLW
EAMHDPKERERIKRARPLPNAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References