Detailed information of TA system TA276249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3691951..3693649
• Replicon: chromosome
• Accession: NZ_CP121297
• Organism: Salmonella enterica subsp. enterica strain KKP 1762

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: P1N06_RS18025
• Protein ID: WP_076737406.1
• Coordinates: 3692720..3693649 (+)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: P1N06_RS18020
• Protein ID: WP_176202033.1
• Coordinates: 3691951..3692733 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P1N06_RS17990 (3687523)	3687523..3687738	-	216	WP_076737724.1	helix-turn-helix transcriptional regulator	-
P1N06_RS17995 (3687741)	3687741..3688203	-	463	Protein_3497	hypothetical protein	-
P1N06_RS18000 (3688776)	3688776..3688922	+	147	WP_232234239.1	hypothetical protein	-
P1N06_RS18005 (3689047)	3689047..3690015	+	969	WP_232234240.1	DUF3644 domain-containing protein	-
P1N06_RS18010 (3690098)	3690098..3690892	-	795	WP_076737404.1	hypothetical protein	-
P1N06_RS18015 (3690933)	3690933..3691802	-	870	WP_076737405.1	hypothetical protein	-
P1N06_RS18020 (3691951)	3691951..3692733	+	783	WP_176202033.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
P1N06_RS18025 (3692720)	3692720..3693649	+	930	WP_076737406.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
P1N06_RS18030 (3693874)	3693874..3695031	-	1158	WP_076737407.1	DUF3322 domain-containing protein	-
P1N06_RS18035 (3695033)	3695033..3698320	-	3288	WP_076737408.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3687523..3716560	29037

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-261)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35094.43 Da
• Isoelectric Point: 6.3527

>T276249 WP_076737406.1 NZ_CP121297:3692720-3693649 [Salmonella enterica subsp. enterica]
MDLRDSYARQVRLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKAYADRDTDLATINDALMRITESLNGR
PGITAIRQENKADEKRIIVNTADAQIKIEVSPVWRGLLLPATEMPVCEQVEMEYGFTTMNVVSQADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPIAELLAPNWDTSRIATLYAQEFSGMTQRETSLESLLSVTTLLPQTL
KSHLTDRDRQFLLSYKQITPDWSLYRYPEIQHLPAIRWKLRNLAVLKEKNPAKYAATVNKLEGVLEQYF

Nucleotide

• Length: 930 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29289.47 Da
• Isoelectric Point: 7.8227

>AT276249 WP_176202033.1 NZ_CP121297:3691951-3692733 [Salmonella enterica subsp. enterica]
MPNYLNWLMQNTQPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSAMFVTLYTSGLTVDVTPFTTTLNIGDRQLTGSVPELAAYEIA
GGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFRYLDQSDIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp