Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1089168..1089788 Replicon chromosome
Accession NZ_CP121297
Organism Salmonella enterica subsp. enterica strain KKP 1762

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1N06_RS05010 Protein ID WP_001280991.1
Coordinates 1089168..1089386 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1N06_RS05015 Protein ID WP_000344807.1
Coordinates 1089414..1089788 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1N06_RS04970 (1084392) 1084392..1084961 + 570 WP_000779801.1 YbaY family lipoprotein -
P1N06_RS04975 (1084994) 1084994..1085383 - 390 WP_278208425.1 MGMT family protein -
P1N06_RS04985 (1085614) 1085614..1087164 - 1551 WP_023210786.1 EAL domain-containing protein -
P1N06_RS04990 (1087389) 1087389..1087650 + 262 Protein_962 type B 50S ribosomal protein L31 -
P1N06_RS04995 (1087656) 1087656..1087796 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1N06_RS05000 (1087852) 1087852..1088322 - 471 WP_080170962.1 YlaC family protein -
P1N06_RS05005 (1088438) 1088438..1088989 - 552 WP_001278793.1 maltose O-acetyltransferase -
P1N06_RS05010 (1089168) 1089168..1089386 - 219 WP_001280991.1 HHA domain-containing protein Toxin
P1N06_RS05015 (1089414) 1089414..1089788 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1N06_RS05020 (1090284) 1090284..1093433 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1N06_RS05025 (1093456) 1093456..1094649 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T276242 WP_001280991.1 NZ_CP121297:c1089386-1089168 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT276242 WP_000344807.1 NZ_CP121297:c1089788-1089414 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References