Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 441543..442186 Replicon chromosome
Accession NZ_CP121297
Organism Salmonella enterica subsp. enterica strain KKP 1762

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag P1N06_RS02015 Protein ID WP_000048134.1
Coordinates 441543..441959 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag P1N06_RS02020 Protein ID WP_001261294.1
Coordinates 441956..442186 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1N06_RS01995 (436580) 436580..437713 + 1134 WP_076737649.1 amidohydrolase/deacetylase family metallohydrolase -
P1N06_RS02000 (437697) 437697..438815 + 1119 WP_076737650.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P1N06_RS02005 (438812) 438812..439552 + 741 WP_048591337.1 KDGP aldolase family protein -
P1N06_RS02010 (439569) 439569..441482 + 1914 WP_149866235.1 BglG family transcription antiterminator -
P1N06_RS02015 (441543) 441543..441959 - 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
P1N06_RS02020 (441956) 441956..442186 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P1N06_RS02025 (442353) 442353..442817 - 465 WP_076737652.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P1N06_RS02030 (443034) 443034..445172 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T276240 WP_000048134.1 NZ_CP121297:c441959-441543 [Salmonella enterica subsp. enterica]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT276240 WP_001261294.1 NZ_CP121297:c442186-441956 [Salmonella enterica subsp. enterica]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References