Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870738..871392 Replicon chromosome
Accession NZ_CP121151
Organism Escherichia coli strain E47

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag P6H31_RS04300 Protein ID WP_000244772.1
Coordinates 870985..871392 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P6H31_RS04295 Protein ID WP_000354046.1
Coordinates 870738..871004 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H31_RS04270 (866026) 866026..866769 + 744 WP_000951964.1 SDR family oxidoreductase -
P6H31_RS04275 (866826) 866826..868259 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
P6H31_RS04280 (868304) 868304..868615 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
P6H31_RS04285 (868779) 868779..869438 + 660 WP_000250274.1 hemolysin III family protein -
P6H31_RS04290 (869515) 869515..870495 - 981 WP_096857157.1 tRNA-modifying protein YgfZ -
P6H31_RS04295 (870738) 870738..871004 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P6H31_RS04300 (870985) 870985..871392 + 408 WP_000244772.1 protein YgfX Toxin
P6H31_RS04305 (871432) 871432..871953 - 522 WP_001055874.1 flavodoxin FldB -
P6H31_RS04310 (872065) 872065..872961 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P6H31_RS04315 (872986) 872986..873696 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P6H31_RS04320 (873702) 873702..875435 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T275900 WP_000244772.1 NZ_CP121151:870985-871392 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275900 WP_000354046.1 NZ_CP121151:870738-871004 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References