Detailed information of TA system TA275629

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3878006..3878420
• Replicon: chromosome
• Accession: NZ_CP121075
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain R22.2574

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: P8I05_RS18920
• Protein ID: WP_023243487.1
• Coordinates: 3878163..3878420 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3878006..3878338 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P8I05_RS18890	3873259..3873822	-	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-
P8I05_RS18895	3874521..3875222	-	702	Protein_3679	integrase core domain-containing protein	-
P8I05_RS18900	3875275..3875589	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
P8I05_RS18905	3875656..3875934	-	279	WP_077677834.1	hypothetical protein	-
P8I05_RS18910	3876251..3876718	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
P8I05_RS18915	3877536..3877829	-	294	WP_039515457.1	hypothetical protein	-
-	3878006..3878338	-	333	-	-	Antitoxin
P8I05_RS18920	3878163..3878420	+	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
P8I05_RS18925	3878487..3878831	-	345	WP_023218822.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	hsiJ1	3856025..3901417	45392
	-	flank	IS/Tn	-	-	3874521..3874799	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T275629 WP_023243487.1 NZ_CP121075:3878163-3878420 [Salmonella enterica subsp. enterica serovar Infantis]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT275629 NZ_CP121075:c3878338-3878006 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin