Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411420..3412040 Replicon chromosome
Accession NZ_CP121003
Organism Salmonella enterica strain 31A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P6590_RS16810 Protein ID WP_001280991.1
Coordinates 3411822..3412040 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P6590_RS16805 Protein ID WP_000344807.1
Coordinates 3411420..3411794 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6590_RS16795 (3406559) 3406559..3407752 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P6590_RS16800 (3407775) 3407775..3410924 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P6590_RS16805 (3411420) 3411420..3411794 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P6590_RS16810 (3411822) 3411822..3412040 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P6590_RS16815 (3412219) 3412219..3412770 + 552 WP_001278793.1 maltose O-acetyltransferase -
P6590_RS16820 (3412888) 3412888..3413358 + 471 WP_000136183.1 YlaC family protein -
P6590_RS16825 (3413414) 3413414..3413554 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P6590_RS16830 (3413560) 3413560..3413820 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P6590_RS16835 (3414045) 3414045..3415595 + 1551 WP_000213140.1 EAL domain-containing protein -
P6590_RS16845 (3415826) 3415826..3416215 + 390 WP_000961287.1 MGMT family protein -
P6590_RS16850 (3416248) 3416248..3416817 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275523 WP_001280991.1 NZ_CP121003:3411822-3412040 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275523 WP_000344807.1 NZ_CP121003:3411420-3411794 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References