Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2751174..2752762 Replicon chromosome
Accession NZ_CP120847
Organism Klebsiella pneumoniae strain KPHRJ

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P5D18_RS13445 Protein ID WP_004179815.1
Coordinates 2751174..2752496 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P5D18_RS13450 Protein ID WP_004176198.1
Coordinates 2752496..2752762 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5D18_RS13430 (2746230) 2746230..2748731 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
P5D18_RS13435 (2748719) 2748719..2749723 + 1005 WP_004179822.1 fimbrial protein -
P5D18_RS13440 (2749865) 2749865..2751157 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
P5D18_RS13445 (2751174) 2751174..2752496 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
P5D18_RS13450 (2752496) 2752496..2752762 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P5D18_RS13455 (2753028) 2753028..2753354 - 327 WP_002904788.1 hydroxyisourate hydrolase -
P5D18_RS13460 (2753351) 2753351..2753851 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P5D18_RS13465 (2753829) 2753829..2755208 - 1380 WP_094932908.1 nucleobase:cation symporter-2 family protein -
P5D18_RS13470 (2755554) 2755554..2756708 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
P5D18_RS13475 (2756689) 2756689..2757612 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T275422 WP_004179815.1 NZ_CP120847:c2752496-2751174 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT275422 WP_004176198.1 NZ_CP120847:c2752762-2752496 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References