Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4488354..4488956 Replicon chromosome
Accession NZ_CP120837
Organism Salmonella enterica subsp. enterica strain 21A

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag P4B21_RS21805 Protein ID WP_001159635.1
Coordinates 4488645..4488956 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P4B21_RS21800 Protein ID WP_000362050.1
Coordinates 4488354..4488644 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B21_RS21785 (4485847) 4485847..4486749 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
P4B21_RS21790 (4486746) 4486746..4487381 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P4B21_RS21795 (4487378) 4487378..4488307 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
P4B21_RS21800 (4488354) 4488354..4488644 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P4B21_RS21805 (4488645) 4488645..4488956 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P4B21_RS21810 (4489174) 4489174..4490103 + 930 WP_001127705.1 alpha/beta hydrolase -
P4B21_RS21815 (4490189) 4490189..4490500 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
P4B21_RS21820 (4490497) 4490497..4490943 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
P4B21_RS21825 (4490958) 4490958..4491899 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P4B21_RS21830 (4491944) 4491944..4492381 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
P4B21_RS21835 (4492378) 4492378..4493250 - 873 WP_000921423.1 virulence factor BrkB family protein -
P4B21_RS21840 (4493244) 4493244..4493843 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T275410 WP_001159635.1 NZ_CP120837:c4488956-4488645 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT275410 WP_000362050.1 NZ_CP120837:c4488644-4488354 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References