Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 3963064..3963765 Replicon chromosome
Accession NZ_CP120633
Organism Escherichia coli strain USVAST219

Toxin (Protein)


Gene name ykfI Uniprot ID A0A515RBV3
Locus tag P6O79_RS19490 Protein ID WP_001531265.1
Coordinates 3963430..3963765 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag P6O79_RS19485 Protein ID WP_032143152.1
Coordinates 3963064..3963399 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6O79_RS19460 (3959011) 3959011..3959229 - 219 WP_001531256.1 AlpA family phage regulatory protein -
P6O79_RS19465 (3959347) 3959347..3959961 - 615 WP_001531257.1 inovirus Gp2 family protein -
P6O79_RS19470 (3960554) 3960554..3961507 + 954 WP_001531259.1 hypothetical protein -
P6O79_RS19475 (3961743) 3961743..3962561 + 819 WP_001531260.1 DUF932 domain-containing protein -
P6O79_RS19480 (3962591) 3962591..3963064 + 474 WP_001531261.1 DNA repair protein RadC -
P6O79_RS19485 (3963064) 3963064..3963399 + 336 WP_032143152.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
P6O79_RS19490 (3963430) 3963430..3963765 + 336 WP_001531265.1 TA system toxin CbtA family protein Toxin
P6O79_RS19495 (3963896) 3963896..3964729 + 834 WP_001531266.1 DUF4942 domain-containing protein -
P6O79_RS19500 (3964806) 3964806..3965054 + 249 WP_024187601.1 ribbon-helix-helix domain-containing protein -
P6O79_RS19505 (3965058) 3965058..3965333 + 276 WP_001531268.1 type II toxin-antitoxin system RelE/ParE family toxin -
P6O79_RS19510 (3965447) 3965447..3966244 + 798 WP_001531269.1 helix-turn-helix transcriptional regulator -
P6O79_RS19515 (3966655) 3966655..3966826 + 172 Protein_3815 integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(11-110)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12867.89 Da        Isoelectric Point: 9.8953

>T275305 WP_001531265.1 NZ_CP120633:3963430-3963765 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQILLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRRHNTP

Download         Length: 336 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12505.48 Da        Isoelectric Point: 7.1637

>AT275305 WP_032143152.1 NZ_CP120633:3963064-3963399 [Escherichia coli]
MLQKDKVMQQECGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADDELSACQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A515RBV3

Antitoxin

Source ID Structure

References