Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2578003..2579591 Replicon chromosome
Accession NZ_CP120549
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name hipA Uniprot ID A0A192ENQ5
Locus tag P5710_RS12375 Protein ID WP_001125432.1
Coordinates 2578269..2579591 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V0VAH2
Locus tag P5710_RS12370 Protein ID WP_001304368.1
Coordinates 2578003..2578269 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS12355 (2574371) 2574371..2575822 + 1452 WP_001518609.1 tagaturonate reductase -
P5710_RS12360 (2576019) 2576019..2576933 + 915 WP_001313828.1 bestrophin family protein -
P5710_RS12365 (2576937) 2576937..2577695 - 759 WP_001286543.1 trans-aconitate 2-methyltransferase -
P5710_RS12370 (2578003) 2578003..2578269 + 267 WP_001304368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P5710_RS12375 (2578269) 2578269..2579591 + 1323 WP_001125432.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
P5710_RS12380 (2579753) 2579753..2580271 - 519 Protein_2427 acetylxylan esterase -
P5710_RS12385 (2580718) 2580718..2581212 + 495 WP_001337831.1 AEC family transporter -
P5710_RS12390 (2581214) 2581214..2581561 + 348 WP_001337832.1 hypothetical protein -
P5710_RS12395 (2581643) 2581643..2581885 + 243 Protein_2430 two-component sensor histidine kinase -
P5710_RS12400 (2582063) 2582063..2582428 + 366 WP_000274389.1 cupin domain-containing protein -
P5710_RS12405 (2582406) 2582406..2583167 + 762 WP_001066620.1 carboxymuconolactone decarboxylase family protein -
P5710_RS12410 (2583325) 2583325..2584389 + 1065 WP_000859696.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49297.02 Da        Isoelectric Point: 8.6972

>T275106 WP_001125432.1 NZ_CP120549:2578269-2579591 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9957.31 Da        Isoelectric Point: 4.9632

>AT275106 WP_001304368.1 NZ_CP120549:2578003-2578269 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192ENQ5

Antitoxin

Source ID Structure
AlphaFold DB V0VAH2

References