Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 782851..783499 Replicon chromosome
Accession NZ_CP120397
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1521-2017_CI

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag PVA76_RS03710 Protein ID WP_000244762.1
Coordinates 783098..783499 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PVA76_RS03705 Protein ID WP_000351186.1
Coordinates 782851..783117 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA76_RS03685 (PVA76_03685) 778779..780212 - 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -
PVA76_RS03690 (PVA76_03690) 780371..780682 + 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
PVA76_RS03695 (PVA76_03695) 780846..781505 + 660 WP_000250289.1 hemolysin III family protein -
PVA76_RS03700 (PVA76_03700) 781621..782601 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
PVA76_RS03705 (PVA76_03705) 782851..783117 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PVA76_RS03710 (PVA76_03710) 783098..783499 + 402 WP_000244762.1 protein YgfX Toxin
PVA76_RS03715 (PVA76_03715) 783564..784085 - 522 WP_001055885.1 flavodoxin FldB -
PVA76_RS03720 (PVA76_03720) 784198..785094 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PVA76_RS03725 (PVA76_03725) 785118..785831 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PVA76_RS03730 (PVA76_03730) 785837..787570 + 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T275022 WP_000244762.1 NZ_CP120397:783098-783499 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT275022 WP_000351186.1 NZ_CP120397:782851-783117 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References