Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 88799..89389 Replicon plasmid pESI
Accession NZ_CP120328
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_10_2021

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag P1825_RS24285 Protein ID WP_023994178.1
Coordinates 89057..89389 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag P1825_RS24280 Protein ID WP_023994179.1
Coordinates 88799..89056 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1825_RS24260 (P1825_24260) 84298..85323 + 1026 WP_023994180.1 IS630 family transposase -
P1825_RS24265 (P1825_24265) 85327..86346 - 1020 WP_223155817.1 hypothetical protein -
P1825_RS24270 (P1825_24270) 86486..86992 - 507 WP_223155815.1 hypothetical protein -
P1825_RS24275 (P1825_24275) 87103..88188 - 1086 WP_223155813.1 hypothetical protein -
P1825_RS24280 (P1825_24280) 88799..89056 + 258 WP_023994179.1 hypothetical protein Antitoxin
P1825_RS24285 (P1825_24285) 89057..89389 + 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P1825_RS24290 (P1825_24290) 89989..90594 + 606 Protein_99 IS481 family transposase -
P1825_RS24295 (P1825_24295) 90893..93116 - 2224 Protein_100 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA14 / ant(3'')-Ia / qacE / sul1 / tet(A) faeC / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..285079 285079
- inside IScluster/Tn - - 84286..90594 6308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11787.54 Da        Isoelectric Point: 9.3417

>T274696 WP_023994178.1 NZ_CP120328:89057-89389 [Salmonella enterica subsp. enterica serovar Muenchen]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGDFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9374.86 Da        Isoelectric Point: 4.4354

>AT274696 WP_023994179.1 NZ_CP120328:88799-89056 [Salmonella enterica subsp. enterica serovar Muenchen]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWMDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References