Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2142349..2142871 Replicon chromosome
Accession NZ_CP119984
Organism Salmonella enterica strain CRIN508879

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P2W29_RS10385 Protein ID WP_000221343.1
Coordinates 2142349..2142633 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag P2W29_RS10390 Protein ID WP_000885426.1
Coordinates 2142623..2142871 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2W29_RS10365 (2138428) 2138428..2139936 - 1509 WP_023993260.1 FAD-dependent oxidoreductase -
P2W29_RS10370 (2139981) 2139981..2140469 + 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
P2W29_RS10375 (2140662) 2140662..2141741 + 1080 WP_278276657.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P2W29_RS10380 (2141789) 2141789..2142178 - 390 WP_023993262.1 RidA family protein -
P2W29_RS10385 (2142349) 2142349..2142633 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P2W29_RS10390 (2142623) 2142623..2142871 - 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P2W29_RS10395 (2143023) 2143023..2143238 + 216 WP_023993263.1 phage protein -
P2W29_RS10400 (2143228) 2143228..2143560 + 333 WP_000253154.1 DUF1493 family protein -
P2W29_RS10405 (2143840) 2143840..2144034 + 195 Protein_2028 hypothetical protein -
P2W29_RS10410 (2144033) 2144033..2144479 - 447 Protein_2029 helix-turn-helix domain-containing protein -
P2W29_RS10415 (2145385) 2145385..2146293 + 909 WP_023994284.1 LysR family transcriptional regulator -
P2W29_RS10420 (2146467) 2146467..2147447 + 981 WP_023993266.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2136991..2149176 12185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T274543 WP_000221343.1 NZ_CP119984:c2142633-2142349 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT274543 WP_000885426.1 NZ_CP119984:c2142871-2142623 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References