Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3617343..3617947 Replicon chromosome
Accession NZ_CP119869
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name higB Uniprot ID A0A1A6FMI3
Locus tag P3C36_RS17340 Protein ID WP_003612979.1
Coordinates 3617630..3617947 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1A6FMG2
Locus tag P3C36_RS17335 Protein ID WP_003612976.1
Coordinates 3617343..3617633 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3C36_RS17300 3612664..3612951 - 288 WP_024749487.1 co-chaperone GroES -
P3C36_RS17305 3613242..3613736 - 495 WP_003612966.1 peptidoglycan-binding protein LysM -
P3C36_RS17310 3613860..3614375 - 516 WP_024749488.1 YchJ family protein -
P3C36_RS17315 3614584..3615843 - 1260 WP_003612971.1 cytochrome c peroxidase -
P3C36_RS17320 3615959..3616459 - 501 WP_003612972.1 DUF2165 domain-containing protein -
P3C36_RS17325 3616615..3616902 + 288 WP_003612973.1 YciI family protein -
P3C36_RS17330 3616902..3617312 + 411 WP_003612974.1 EVE domain-containing protein -
P3C36_RS17335 3617343..3617633 - 291 WP_003612976.1 helix-turn-helix transcriptional regulator Antitoxin
P3C36_RS17340 3617630..3617947 - 318 WP_003612979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P3C36_RS17345 3618132..3619094 + 963 WP_003612980.1 malate dehydrogenase -
P3C36_RS17350 3619171..3620370 + 1200 WP_003612982.1 ADP-forming succinate--CoA ligase subunit beta -
P3C36_RS17355 3620517..3622322 + 1806 WP_099831827.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-86)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12151.32 Da        Isoelectric Point: 10.9010

>T274482 WP_003612979.1 NZ_CP119869:c3617947-3617630 [Methylosinus trichosporium OB3b]
MWSVEYLPAAAEEEAALPIEMQARLARMLDVIRRAGLTNLPRDWVKPLEGKLWELRITGKDGVARAIYVTAEGRRVVIVR
IFVKKTQKTPRRELELARRRAKEVE

Download         Length: 318 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10787.22 Da        Isoelectric Point: 9.5881

>AT274482 WP_003612976.1 NZ_CP119869:c3617633-3617343 [Methylosinus trichosporium OB3b]
MTKTIDARIIHAKRMAEDEAYRAAYDALEEEFALVNSMIEARARSKLSQAEVAKRMGTTESAVSRLESGRGKPSTRTLER
YAEAVGHRLRITFEPS

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A6FMI3

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FMG2

References