Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 627378..628060 Replicon chromosome
Accession NZ_CP119869
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A6FQN5
Locus tag P3C36_RS02895 Protein ID WP_003612262.1
Coordinates 627378..627788 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P3C36_RS02900 Protein ID WP_003612263.1
Coordinates 627797..628060 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3C36_RS02875 623172..624110 + 939 WP_003612258.1 outer membrane beta-barrel protein -
P3C36_RS02880 624180..625289 + 1110 WP_003612259.1 helix-turn-helix transcriptional regulator -
P3C36_RS02885 625379..626510 + 1132 WP_099831788.1 peptide chain release factor 2 -
P3C36_RS02890 626851..627183 + 333 WP_003612261.1 hypothetical protein -
P3C36_RS02895 627378..627788 - 411 WP_003612262.1 type II toxin-antitoxin system VapC family toxin Toxin
P3C36_RS02900 627797..628060 - 264 WP_003612263.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P3C36_RS02905 628133..629989 - 1857 WP_003612264.1 cation:proton antiporter -
P3C36_RS02910 630110..630511 - 402 WP_003612265.1 DUF3775 domain-containing protein -
P3C36_RS02915 630588..631160 - 573 WP_003612266.1 isochorismatase family protein -
P3C36_RS02920 632163..632390 - 228 WP_283472095.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-126)

Antitoxin

SpoVT-AbrB domain

(12-48)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14966.38 Da        Isoelectric Point: 6.7211

>T274477 WP_003612262.1 NZ_CP119869:c627788-627378 [Methylosinus trichosporium OB3b]
MFFLDTNVVIAVMTRRAPHLVARIEAELAHGTPLLLSTIVLYELEYGACKSAHPERNLARIGDFLVSVAAIVPLDVEDAR
EAGDIRAFLEAKGTPIGPYDVLIAAQARRRRIALVTGNRREFDRVPGLVMTDWTAA

Download         Length: 411 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10167.66 Da        Isoelectric Point: 5.1875

>AT274477 WP_003612263.1 NZ_CP119869:c628060-627797 [Methylosinus trichosporium OB3b]
MHEQNKATAKLFMHGRSQAVRLPKEFRFEGSQVRVSRIGDKVILEPMEKPPFDVKAWRAKLDAYLDIDFPEIERIPPLEP
DEDVTFD

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A6FQN5

Antitoxin

Source ID Structure

References