Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3677886..3678108 Replicon chromosome
Accession NC_017638
Organism Escherichia coli DH1

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag ECDH1ME8569_RS18165 Protein ID WP_000141634.1
Coordinates 3677886..3677993 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3678042..3678108 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECDH1ME8569_RS18140 (ECDH1ME8569_3413) 3673139..3673891 - 753 Protein_3465 cellulose biosynthesis protein BcsQ -
ECDH1ME8569_RS18145 (ECDH1ME8569_3414) 3673903..3674091 - 189 WP_001063318.1 YhjR family protein -
ECDH1ME8569_RS18150 (ECDH1ME8569_3415) 3674364..3675935 + 1572 WP_001204931.1 cellulose biosynthesis protein BcsE -
ECDH1ME8569_RS18155 (ECDH1ME8569_3416) 3675932..3676123 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
ECDH1ME8569_RS18160 (ECDH1ME8569_3417) 3676120..3677799 + 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
ECDH1ME8569_RS18165 3677886..3677993 - 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
- 3678042..3678108 + 67 - - Antitoxin
ECDH1ME8569_RS18175 (ECDH1ME8569_3419) 3678469..3679740 + 1272 WP_001295225.1 transporter -
ECDH1ME8569_RS18180 (ECDH1ME8569_3420) 3679770..3680774 - 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
ECDH1ME8569_RS18185 (ECDH1ME8569_3421) 3680771..3681754 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
ECDH1ME8569_RS18190 (ECDH1ME8569_3422) 3681765..3682667 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T27422 WP_000141634.1 NC_017638:c3677993-3677886 [Escherichia coli DH1]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T27422 NC_017638:c3677993-3677886 [Escherichia coli DH1]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT27422 NC_017638:3678042-3678108 [Escherichia coli DH1]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References