Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3435515..3436133 Replicon chromosome
Accession NZ_CP119402
Organism Escherichia coli strain MRE162 substr. FRA

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PX810_RS16755 Protein ID WP_001291435.1
Coordinates 3435915..3436133 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PX810_RS16750 Protein ID WP_000344800.1
Coordinates 3435515..3435889 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX810_RS16740 (3430604) 3430604..3431797 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PX810_RS16745 (3431820) 3431820..3434969 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PX810_RS16750 (3435515) 3435515..3435889 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PX810_RS16755 (3435915) 3435915..3436133 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PX810_RS16760 (3436305) 3436305..3436856 + 552 WP_000102564.1 maltose O-acetyltransferase -
PX810_RS16765 (3436972) 3436972..3437442 + 471 WP_000136192.1 YlaC family protein -
PX810_RS16770 (3437606) 3437606..3439156 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PX810_RS16775 (3439198) 3439198..3439551 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PX810_RS16785 (3439930) 3439930..3440241 + 312 WP_000409911.1 MGMT family protein -
PX810_RS16790 (3440272) 3440272..3440844 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274087 WP_001291435.1 NZ_CP119402:3435915-3436133 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274087 WP_000344800.1 NZ_CP119402:3435515-3435889 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References