Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2411855..2412493 Replicon chromosome
Accession NZ_CP119402
Organism Escherichia coli strain MRE162 substr. FRA

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PX810_RS11720 Protein ID WP_000813794.1
Coordinates 2412317..2412493 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PX810_RS11715 Protein ID WP_077875187.1
Coordinates 2411855..2412271 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX810_RS11695 (2407007) 2407007..2407948 - 942 WP_001251313.1 ABC transporter permease -
PX810_RS11700 (2407949) 2407949..2408962 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
PX810_RS11705 (2408980) 2408980..2410125 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PX810_RS11710 (2410370) 2410370..2411776 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
PX810_RS11715 (2411855) 2411855..2412271 - 417 WP_077875187.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PX810_RS11720 (2412317) 2412317..2412493 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PX810_RS11725 (2412715) 2412715..2412945 + 231 WP_000494244.1 YncJ family protein -
PX810_RS11730 (2413037) 2413037..2414998 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PX810_RS11735 (2415071) 2415071..2415607 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
PX810_RS11740 (2415699) 2415699..2416874 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2417206..2418180 974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T274086 WP_000813794.1 NZ_CP119402:c2412493-2412317 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15260.66 Da        Isoelectric Point: 4.7386

>AT274086 WP_077875187.1 NZ_CP119402:c2412271-2411855 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKI
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References