273937

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4476038..4477296 Replicon chromosome
Accession NZ_CP119298
Organism Pseudomonas aeruginosa strain SNDPR-01

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PZ484_RS20825 Protein ID WP_003163133.1
Coordinates 4476038..4476793 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PZ484_RS20830 Protein ID WP_003086329.1
Coordinates 4476928..4477296 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ484_RS20815 4471210..4473753 + 2544 WP_213870229.1 acyl-homoserine-lactone acylase QuiP -
PZ484_RS20820 4473908..4475269 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PZ484_RS20825 4476038..4476793 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PZ484_RS20830 4476928..4477296 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PZ484_RS20835 4477369..4478655 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PZ484_RS20840 4478711..4480204 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
PZ484_RS20845 4480379..4480855 + 477 WP_034047212.1 hypothetical protein -
PZ484_RS20850 4480858..4481133 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T273937 WP_003163133.1 NZ_CP119298:c4476793-4476038 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT273937 WP_003086329.1 NZ_CP119298:c4477296-4476928 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References