Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843577..844237 Replicon chromosome
Accession NZ_CP119137
Organism Salmonella enterica subsp. enterica serovar Goldcoast isolate Sal02792

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag P0D85_RS05335 Protein ID WP_000244756.1
Coordinates 843824..844237 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P0D85_RS05330 Protein ID WP_000351186.1
Coordinates 843577..843843 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D85_RS05310 (839506) 839506..840939 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
P0D85_RS05315 (841097) 841097..841408 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P0D85_RS05320 (841572) 841572..842231 + 660 WP_000250289.1 hemolysin III family protein -
P0D85_RS05325 (842347) 842347..843327 - 981 WP_023254245.1 tRNA-modifying protein YgfZ -
P0D85_RS05330 (843577) 843577..843843 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P0D85_RS05335 (843824) 843824..844237 + 414 WP_000244756.1 protein YgfX Toxin
P0D85_RS05340 (844290) 844290..844811 - 522 WP_001055885.1 flavodoxin FldB -
P0D85_RS05345 (844924) 844924..845820 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P0D85_RS05350 (845844) 845844..846557 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P0D85_RS05355 (846563) 846563..848296 + 1734 WP_064012850.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T273819 WP_000244756.1 NZ_CP119137:843824-844237 [Salmonella enterica subsp. enterica serovar Goldcoast]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT273819 WP_000351186.1 NZ_CP119137:843577-843843 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References