Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 258783..259414 Replicon chromosome
Accession NZ_CP119076
Organism Klebsiella aerogenes strain RX7.1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PYR66_RS01165 Protein ID WP_275048415.1
Coordinates 258783..259058 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PYR66_RS01170 Protein ID WP_275048416.1
Coordinates 259055..259414 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR66_RS01145 (PYR66_01145) 254010..254345 + 336 WP_275048411.1 universal stress protein UspB -
PYR66_RS01150 (PYR66_01150) 254411..255907 - 1497 WP_275048412.1 inorganic phosphate transporter PitA -
PYR66_RS01155 (PYR66_01155) 256138..257331 + 1194 WP_275048413.1 NAD(P)/FAD-dependent oxidoreductase -
PYR66_RS01160 (PYR66_01160) 257371..258384 - 1014 WP_275048414.1 magnesium transporter -
PYR66_RS01165 (PYR66_01165) 258783..259058 + 276 WP_275048415.1 type II toxin-antitoxin system HicA family toxin Toxin
PYR66_RS01170 (PYR66_01170) 259055..259414 + 360 WP_275048416.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PYR66_RS01175 (PYR66_01175) 259917..261056 + 1140 WP_275048417.1 UDP-4-amino-4-deoxy-L-arabinose aminotransferase -
PYR66_RS01180 (PYR66_01180) 261058..262041 + 984 WP_275048418.1 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase -
PYR66_RS01185 (PYR66_01185) 262038..264023 + 1986 WP_275048419.1 bifunctional UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronic acid oxidase ArnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10286.94 Da        Isoelectric Point: 10.6838

>T273731 WP_275048415.1 NZ_CP119076:258783-259058 [Klebsiella aerogenes]
MERQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13227.00 Da        Isoelectric Point: 4.4118

>AT273731 WP_275048416.1 NZ_CP119076:259055-259414 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLLQEGEISLQEYLADCQQAGIDPYVHPEKIKT
FTLRYPESFGERLSSAAAEEQVSVNTWILEALSERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References