Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2572856..2574444 Replicon chromosome
Accession NZ_CP118936
Organism Klebsiella pneumoniae subsp. pneumoniae strain RX.G5M15

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag PX704_RS12610 Protein ID WP_004199851.1
Coordinates 2572856..2574178 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PX704_RS12615 Protein ID WP_002904790.1
Coordinates 2574178..2574444 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX704_RS12595 (2567912) 2567912..2570413 + 2502 WP_218785401.1 fimbria/pilus outer membrane usher protein -
PX704_RS12600 (2570401) 2570401..2571405 + 1005 WP_275107629.1 fimbrial protein -
PX704_RS12605 (2571547) 2571547..2572839 + 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
PX704_RS12610 (2572856) 2572856..2574178 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
PX704_RS12615 (2574178) 2574178..2574444 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PX704_RS12620 (2574710) 2574710..2575036 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PX704_RS12625 (2575033) 2575033..2575533 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PX704_RS12630 (2575511) 2575511..2576890 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
PX704_RS12635 (2577236) 2577236..2578390 + 1155 WP_029602402.1 FAD-dependent urate hydroxylase HpxO -
PX704_RS12640 (2578371) 2578371..2579294 - 924 WP_023287634.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T273613 WP_004199851.1 NZ_CP118936:c2574178-2572856 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT273613 WP_002904790.1 NZ_CP118936:c2574444-2574178 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References