Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 868577..869231 Replicon chromosome
Accession NZ_CP118927
Organism Citrobacter koseri strain L2395

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag PX343_RS04175 Protein ID WP_024130921.1
Coordinates 868824..869231 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag PX343_RS04170 Protein ID WP_024130922.1
Coordinates 868577..868843 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX343_RS04145 (PX343_04145) 863721..865154 - 1434 WP_115625884.1 6-phospho-beta-glucosidase BglA -
PX343_RS04150 (PX343_04150) 865275..866003 - 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
PX343_RS04155 (PX343_04155) 866056..866367 + 312 WP_049008973.1 N(4)-acetylcytidine aminohydrolase -
PX343_RS04160 (PX343_04160) 866529..867188 + 660 WP_012135004.1 hemolysin III family protein -
PX343_RS04165 (PX343_04165) 867340..868320 - 981 WP_275055549.1 tRNA-modifying protein YgfZ -
PX343_RS04170 (PX343_04170) 868577..868843 + 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
PX343_RS04175 (PX343_04175) 868824..869231 + 408 WP_024130921.1 protein YgfX Toxin
PX343_RS04180 (PX343_04180) 869329..869853 - 525 WP_012134999.1 flavodoxin FldB -
PX343_RS04185 (PX343_04185) 869957..870853 + 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
PX343_RS04190 (PX343_04190) 870877..871590 + 714 WP_049008968.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PX343_RS04195 (PX343_04195) 871596..873329 + 1734 WP_049008966.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T273572 WP_024130921.1 NZ_CP118927:868824-869231 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT273572 WP_024130922.1 NZ_CP118927:868577-868843 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References