Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 74629..75461 Replicon chromosome
Accession NZ_CP118927
Organism Citrobacter koseri strain L2395

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VCF5
Locus tag PX343_RS00345 Protein ID WP_000854681.1
Coordinates 74629..75006 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag PX343_RS00350 Protein ID WP_088474659.1
Coordinates 75096..75461 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX343_RS00320 (PX343_00320) 70813..71820 - 1008 WP_115180953.1 zinc-binding alcohol dehydrogenase family protein -
PX343_RS00325 (PX343_00325) 71932..72840 + 909 WP_058668296.1 LysR family transcriptional regulator -
PX343_RS00330 (PX343_00330) 73283..74125 - 843 WP_096939511.1 DUF4942 domain-containing protein -
PX343_RS00335 (PX343_00335) 74210..74407 - 198 WP_023563519.1 DUF957 domain-containing protein -
PX343_RS00340 (PX343_00340) 74435..74632 - 198 Protein_67 DUF5983 family protein -
PX343_RS00345 (PX343_00345) 74629..75006 - 378 WP_000854681.1 TA system toxin CbtA family protein Toxin
PX343_RS00350 (PX343_00350) 75096..75461 - 366 WP_088474659.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PX343_RS00355 (PX343_00355) 75539..75760 - 222 WP_000692300.1 DUF987 domain-containing protein -
PX343_RS00360 (PX343_00360) 75823..76299 - 477 WP_001424026.1 RadC family protein -
PX343_RS00365 (PX343_00365) 76315..76800 - 486 WP_000206658.1 antirestriction protein -
PX343_RS00370 (PX343_00370) 76892..77710 - 819 WP_001234615.1 DUF932 domain-containing protein -
PX343_RS00375 (PX343_00375) 77809..78042 - 234 WP_001278287.1 DUF905 family protein -
PX343_RS00380 (PX343_00380) 78048..78725 - 678 WP_001097305.1 hypothetical protein -
PX343_RS00385 (PX343_00385) 78873..79553 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13963.89 Da        Isoelectric Point: 7.4348

>T273570 WP_000854681.1 NZ_CP118927:c75006-74629 [Citrobacter koseri]
MKTLPDTHIREASHCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTSHNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13554.36 Da        Isoelectric Point: 6.2034

>AT273570 WP_088474659.1 NZ_CP118927:c75461-75096 [Citrobacter koseri]
VSDTLPGTTYPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKT

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VCF5

Antitoxin

Source ID Structure

References