Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 741874..742413 Replicon chromosome
Accession NZ_CP118776
Organism Mammaliicoccus lentus strain 7074

Toxin (Protein)


Gene name mazF Uniprot ID A0A178P0V5
Locus tag PYH61_RS03715 Protein ID WP_016999692.1
Coordinates 742042..742413 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A4Y9KBD3
Locus tag PYH61_RS03710 Protein ID WP_016999693.1
Coordinates 741874..742041 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH61_RS03685 (PYH61_03685) 737735..738214 + 480 WP_282822110.1 PH domain-containing protein -
PYH61_RS03690 (PYH61_03690) 738204..739736 + 1533 WP_103268922.1 PH domain-containing protein -
PYH61_RS03695 (PYH61_03695) 739726..740226 + 501 WP_064204141.1 PH domain-containing protein -
PYH61_RS03700 (PYH61_03700) 740223..740591 + 369 WP_064204140.1 holo-ACP synthase -
PYH61_RS03705 (PYH61_03705) 740639..741787 + 1149 WP_103268921.1 alanine racemase -
PYH61_RS03710 (PYH61_03710) 741874..742041 + 168 WP_016999693.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYH61_RS03715 (PYH61_03715) 742042..742413 + 372 WP_016999692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYH61_RS03720 (PYH61_03720) 742517..743521 + 1005 WP_064204137.1 PP2C family protein-serine/threonine phosphatase -
PYH61_RS03725 (PYH61_03725) 743594..743920 + 327 WP_016999690.1 anti-sigma factor antagonist -
PYH61_RS03730 (PYH61_03730) 743922..744398 + 477 WP_016999689.1 anti-sigma B factor RsbW -
PYH61_RS03735 (PYH61_03735) 744373..745143 + 771 WP_103268920.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13662.79 Da        Isoelectric Point: 9.8460

>T273439 WP_016999692.1 NZ_CP118776:742042-742413 [Mammaliicoccus lentus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDSAIAISLNLTLQYKFDTLGNT

Download         Length: 372 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6239.71 Da        Isoelectric Point: 4.0121

>AT273439 WP_016999693.1 NZ_CP118776:741874-742041 [Mammaliicoccus lentus]
MTSLTQNRNQSLEQTLKEGYRYMADLNLSLASEAYYSECEACDSNESHLTSQQGE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178P0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y9KBD3

References