Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 157177..157682 Replicon chromosome
Accession NZ_CP118641
Organism Pseudomonas aeruginosa strain P23

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag PUL49_RS00715 Protein ID WP_003121619.1
Coordinates 157177..157458 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag PUL49_RS00720 Protein ID WP_003112628.1
Coordinates 157455..157682 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUL49_RS00690 (PUL49_00690) 152428..153777 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PUL49_RS00695 (PUL49_00695) 153826..154512 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PUL49_RS00700 (PUL49_00700) 154613..155347 + 735 WP_043095998.1 GntR family transcriptional regulator -
PUL49_RS00705 (PUL49_00705) 155527..155937 + 411 WP_003101225.1 aegerolysin family protein -
PUL49_RS00710 (PUL49_00710) 155969..156877 - 909 WP_016561475.1 LysR family transcriptional regulator -
PUL49_RS00715 (PUL49_00715) 157177..157458 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
PUL49_RS00720 (PUL49_00720) 157455..157682 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
PUL49_RS00725 (PUL49_00725) 157858..158478 - 621 WP_003101226.1 hypothetical protein -
PUL49_RS00730 (PUL49_00730) 158579..159079 + 501 WP_003101228.1 LEA type 2 family protein -
PUL49_RS00735 (PUL49_00735) 159152..159493 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PUL49_RS00740 (PUL49_00740) 159575..161002 - 1428 WP_003083784.1 GABA permease -
PUL49_RS00745 (PUL49_00745) 161171..162664 - 1494 WP_043095997.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T273358 WP_003121619.1 NZ_CP118641:c157458-157177 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT273358 WP_003112628.1 NZ_CP118641:c157682-157455 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References