Detailed information of TA system TA273343

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3729225..3729639
• Replicon: chromosome
• Accession: NZ_CP118633
• Organism: Salmonella enterica subsp. enterica serovar Anatum strain 2089b

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: PWO88_RS18390
• Protein ID: WP_023243487.1
• Coordinates: 3729382..3729639 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3729225..3729557 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PWO88_RS18360	3724493..3724987	-	495	WP_023228257.1	Saf-pilin pilus formation protein SafA	-
PWO88_RS18365	3725743..3726447	-	705	Protein_3602	integrase core domain-containing protein	-
PWO88_RS18370	3726500..3726814	+	315	WP_080155293.1	SymE family type I addiction module toxin	-
PWO88_RS18375	3726881..3727159	-	279	WP_012543321.1	hypothetical protein	-
PWO88_RS18380	3727475..3727942	-	468	WP_023244346.1	hypothetical protein	-
PWO88_RS18385	3728815..3729048	-	234	WP_125462689.1	hypothetical protein	-
-	3729225..3729557	-	333	-	-	Antitoxin
PWO88_RS18390	3729382..3729639	+	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
PWO88_RS18395	3729698..3730006	-	309	WP_023216761.1	hypothetical protein	-
PWO88_RS18400	3730024..3730401	-	378	WP_024149347.1	DUF4329 domain-containing protein	-
PWO88_RS18405	3730792..3731313	-	522	WP_023243488.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3716068..3731313	15245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T273343 WP_023243487.1 NZ_CP118633:3729382-3729639 [Salmonella enterica subsp. enterica serovar Anatum]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT273343 NZ_CP118633:c3729557-3729225 [Salmonella enterica subsp. enterica serovar Anatum]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin